J Eur Acad Dermatol Venereol. View abstract. N.Engl.J.Med. Perez, A., Chen, T. C., Turner, A., Raab, R., Bhawan, J., Poche, P., and Holick, M. F. Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin d3) for the treatment of psoriasis. View abstract. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. Ragi-Eis, S., Zerbini, C. A., Provenza, J. R., Griz, L. H., de Gregorio, L. H., Russo, L. A., Silva, N. A., Borges, J. L., de Souza, A. C., Castro, M. L., and Lewiecki, E. M. Is it ethical to use placebos in osteoporosis trials? Br J Dermatol 2003;148(2):318-325. Nephrol.Dial.Transplant. Imanishi, Y. and Nishizawa, Y. View abstract. Br.J Dermatol. Short term and long term safety of weekly high dose vitamin D3 supplementation in schoolchildren. View abstract. Abstract 1755. A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study. View abstract. WebMD does not provide medical advice, diagnosis or treatment. [106] Vitamin D supplementation is also likely to reduce the risk of gestational diabetes, undersized babies[105] and of their poor rate of growth. Wells, G., Tugwell, P., Shea, B., Guyatt, G., Peterson, J., Zytaruk, N., Robinson, V., Henry, D., O'Connell, D., and Cranney, A. Meta-analyses of therapies for postmenopausal osteoporosis. [10][11][197], There is conflicting evidence about the benefits of interventions with vitamin D,[198] one view purporting an intake of 4,000–12,000 IU/day from sun exposure with concomitant serum 25-hydroxyvitamin D levels of 40 to 80 ng/mL,[199] while another view is that serum concentrations above 50 ng/mL are not plausible. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. 2016;176(2):175-83. J Clin Endocrinol Metab 1988;67(4):644-650. Cancer Res 5-15-1999;59(10):2332-2334. Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women: association with estrogen receptor-alpha genotypes. View abstract. View abstract. Oken, E., Ning, Y., Rifas-Shiman, S. L., Rich-Edwards, J. W., Olsen, S. F., and Gillman, M. W. Diet during pregnancy and risk of preeclampsia or gestational hypertension. Snyman, J. R., de, Sommers K., Steinmann, M. A., and Lizamore, D. J. View abstract. The vitamin D and cancer conundrum: aiming at a moving target. Maxwell, D. R., Benjamin, D. M., Donahay, S. L., Allen, M. K., Hamburger, R. J., and Luft, F. C. Calcitriol in dialysis patients. View abstract. Placebo-controlled prospective study with 1,25-dihydroxy vitamin D3. In 1922, Elmer McCollum tested modified cod liver oil in which the vitamin A had been destroyed. View abstract. View abstract. [14], Another 2014 review concluded that vitamin D3 may decrease the risk of death from cancer (one fewer death in 150 people treated over 5 years), but concerns with the quality of the data were noted. Pittas AG, Dawson-Hughes B, Sheehan P, et al. View abstract. View abstract. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Staehelin, H. B., Orav, J. E., Stuck, A. E., Theiler, R., Wong, J. Am J Clin Nutr 2008;88(2):513S-519S. New York: Commonwealth Fund 1934; Theodoratou, E., Farrington, S. M., Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, R. A., Porteous, M. E., Dunlop, M. G., and Campbell, H. Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Handunnetthi, L., Ramagopalan, S. V., and Ebers, G. C. Multiple sclerosis, vitamin D, and HLA-DRB1*15. Z., Kotchen, J., Anderson, G., Brzyski, R., Cauley, J. View abstract. Strause L, Saltman P, Smith KT, et al. View abstract. View abstract. J Bone Miner.Res 2002;17(5):891-897. Papapoulos, S. E., Quandt, S. A., Liberman, U. Oral calcitriol as a new therapeutic modality for generalized morphea. View abstract. 2012;7(3):391-400. 12-15-2005;53(6):821-826. Severe vitamin D deficiency in children causes rickets, a softening and weakening of bones, which is a rare disease in the developed world. Calcipotriol Study Group. Serum 1-OH vitamin D and prognosis of postmenopausal breast cancer patients: NCIC-CTG MA 14 trial[abstract 534]. Neuhouser, M. L., Sorensen, B., Hollis, B. W., Ambs, A., Ulrich, C. M., McTiernan, A., Bernstein, L., Wayne, S., Gilliland, F., Baumgartner, K., Baumgartner, R., and Ballard-Barbash, R. Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors. Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. View abstract. Medicine (Baltimore). Br J Dermatol 2003;148(2):326-333. O'Donnell, S., Moher, D., Thomas, K., Hanley, D. A., and Cranney, A. Intravenous calcitriol for treatment of hyperparathyroidism in children on hemodialysis. View abstract. View abstract. View abstract. View abstract. Studies of young patients with severe osteoporosis. View abstract. Mitri, J., Muraru, M. D., and Pittas, A. G. Vitamin D and type 2 diabetes: a systematic review. Mannion, C. A., Gray-Donald, K., and Koski, K. G. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. Ushiroyama T, Okamura S, Ikeda A, et al. View abstract. View abstract. 1997; Forman, J. P., Bischoff-Ferrari, H. A., Willett, W. C., Stampfer, M. J., and Curhan, G. C. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. JAMA 5-12-2010;303(18):1815-1822. View abstract. View abstract. A., and Nicholson, G. C. Prevention and treatment of glucocorticoid-induced osteoporosis: a comparison of calcitriol, vitamin D plus calcium, and alendronate plus calcium. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Calcium plus vitamin D supplementation and the risk of breast cancer. View abstract. View abstract. View abstract. Am J Clin Nutr 1986;44(6):883-888. Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M; RECORD Trial Group. Avenell, A. and Handoll, H. H. Nutritional supplementation for hip fracture aftercare in the elderly. View abstract. Osteoporos Int 2001;12(2):140-151. Gaugris, S., Heaney, R. P., Boonen, S., Kurth, H., Bentkover, J. D., and Sen, S. S. Vitamin D inadequacy among post-menopausal women: a systematic review. Salmhofer, W., Maier, H., Soyer, H. P., Honigsmann, H., and Hodl, S. Double-blind, placebo-controlled, randomized, right-left study comparing calcipotriol monotherapy with a combined treatment of calcipotriol and diflucortolone valerate in chronic plaque psoriasis. 1997;17(6):505-510. Vitamin D deficiency, muscle function, and falls in elderly people. Some evidence suggests that taking vitamin D supplements might reduce the risk of breast cancer in women who are not yet in menopause but not in women who are already in menopause. View abstract. Eur.Urol. 2019 Nov;18(11):102392. View abstract. View abstract. View abstract. BMJ 2012;345:e6390. Pediatr.Nephrol 2005;20(5):622-630. View abstract. Vitamin D status: effects on parathyroid hormone and 1,25-dihydroxyvitamin D in postmenopausal women. BMJ 2011;342:d192. Yale J Biol Med. AMBULATORY CHILD HEALTH 1997;3(1):56-64. View abstract. Freyschuss, B., Ljunggren, O., Saaf, M., Mellstrom, D., and Avenell, A. Calcium and vitamin D for prevention of osteoporotic fractures. Huncharek, M., Muscat, J., and Kupelnick, B. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Carroll, C., Cooper, K., Papaioannou, D., Hind, D., Pilgrim, H., and Tappenden, P. Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis. BMJ 2011;342:c7254. View abstract. Palacios C, Kostiuk LK, Peña-Rosas JP. Eur J Clin Pharmacol. [44] An increase in the proportion of animal protein[42][45] in the 20th century American diet coupled with increased consumption of milk[46][47] fortified with relatively small quantities of vitamin D coincided with a dramatic decline in the number of rickets cases. Avenell, A., Cook, J. [16] Calcitriol is the most potent natural ligand of the vitamin D receptor, which mediates most of the physiological actions of vitamin D.[2][181], In addition to the kidneys, calcitriol is also synthesized by certain other cells including monocyte-macrophages in the immune system. Clin Evid.(Online.) Dahlman TC. [107] Pregnant women often do not take the recommended amount of vitamin D.[106], Weight loss – Though hypothesized that vitamin D supplementation may be an effective treatment for obesity apart from calorie restriction, one systematic review found no association of supplementation with body weight or fat mass. View abstract. View abstract. View abstract. Growth in children with chronic renal failure on intermittent versus daily calcitriol. Transplant.Proc 2001;33(1-2):1144-1145. 2013;22(11):915-29. Also taking vitamin D might increase calcium and phosphate levels in people with kidney disease. [38][42], Vitamin D deficiency remains the main cause of rickets among young infants in most countries because breast milk is low in vitamin D and social customs and climatic conditions can prevent adequate sun exposure. Diabetologia 1995;38(10):1239-1245. Guillemant, J., Le, H. T., Maria, A., Allemandou, A., Peres, G., and Guillemant, S. Wintertime vitamin D deficiency in male adolescents: effect on parathyroid function and response to vitamin D3 supplements. J Nutr. Bone Marrow Transplant. View abstract. Obstet Gynecol 1986;68(3):300-304. View abstract. 1988;1(4 Pt 1):397-402. Plotnikoff, G. A. 2008;37(1):113-119. In which the body changes vitamin D. this might decrease disease activity in patients with secondary hyperparathyroidism in children ML. Nutrition and spending less time outdoors, Wardman AG, Dawson-Hughes B, Sheehan P, al! Renal magnesium wasting in a form that it can use, Elserogy YM, al! Dermatol 1997 ; 3 ( 1 ):16-22 structured exercise program for frail home! 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